Beilstein J. Org. Chem.2021,17, 245–272, doi:10.3762/bjoc.17.25
.17.25 Abstract Recently, the functionalization of organic molecules with fluorine substituents has grown rapidly due to its applications in such fields as medicine, agriculture or materials sciences. The aim of this article is to review the importance of 1,1-difluorocyclopropanederivatives in synthesis
activity; cyclopropanation; difluorocyclopropanederivatives; synthesis; Introduction
The chemistry of cyclopropane derivatives is one of the most intensively developing fields of organic chemistry. In the past decade there have been made many investigations to develop new chemo-, regio- and
into TBAB and difluorocarbene, which then can react with alkenes producing the gem-difluorocyclopropanederivatives such as 4 (Scheme 5) [21].
Chlorodifluoromethane as a source of difluorocarbene in the reaction: The advantage of using of tetraarylarsonium salts as effective phase-transfer catalysts
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Graphical Abstract
Scheme 1:
Synthesis of 1,1-difluoro-2,3-dimethylcyclopropane (2).